Allosteric cooperativity in ternary complexes with low symmetry.

Area of Science:

• Supramolecular Chemistry
• Organic Synthesis

Background:

• Naphthotubes are macrocyclic compounds with potential applications in molecular recognition and self-assembly.
• Achieving controlled complexation and cooperativity in supramolecular systems remains a challenge.

Purpose of the Study:

• To synthesize novel naphthotubes incorporating ester linkers.
• To investigate the supramolecular assembly and cooperative binding properties of these new naphthotubes.

Main Methods:

• Synthesis and characterization of two new naphthotubes with ester linkers.
• Investigation of ternary complex formation using syn isomers of ester and ether naphthotubes with a guest and two different hosts.
• Analysis of allosteric cooperativity in the complexation process.

Main Results:

• Successful synthesis and characterization of two novel naphthotubes.
• Demonstration of strong positive allosteric cooperativity in a ternary complex involving a guest and two distinct hosts bound by an ester naphthotube.
• Observation of similar cooperative effects with an ether naphthotube.

Conclusions:

• The newly synthesized ester naphthotubes facilitate strong positive allosteric cooperativity.
• These findings provide a foundation for designing sophisticated supramolecular architectures with enhanced complexity and diversity.
• The study highlights the potential of naphthotube-based systems in advanced molecular assembly.