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Efficacy Of Intravenous Lignocain Vs Sevoflurane In Prevention Of Coughing And Desaturation At Extubation In Children

Rabnawaz Khattak1, Inam Ul Haq2, Tariq Abbasi3

  • 1Combined Military Hospital Abbottabad, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|June 26, 2018
PubMed

Insights

Sevoflurane significantly reduced coughing and desaturation during extubation in young children compared to lignocaine. This finding offers a safer approach to pediatric anesthesia, minimizing respiratory complications post-surgery.

Area of Science:

  • Anesthesiology
  • Pediatric Critical Care
  • Respiratory Medicine

Background:

  • Post-anesthesia respiratory complications, including coughing and desaturation, are common and concerning in pediatric patients.
  • Effective strategies are needed to mitigate these risks during the extubation period.

Purpose of the Study:

  • To compare the efficacy of intravenous lignocaine versus sevoflurane in preventing coughing and desaturation during extubation in children under six years of age.

Main Methods:

  • A randomized controlled trial involving 710 children (3 months to 6 years) undergoing surgery requiring an airway.
  • Patients received either intravenous lignocaine or sevoflurane for 3 minutes prior to extubation.
  • Coughing severity and oxygen saturation were assessed for 5 minutes post-extubation.

Main Results:

  • Sevoflurane group showed significantly fewer coughing episodes (56%) compared to the lignocaine group (76%).
  • Desaturation events were markedly lower in the sevoflurane group (8%) versus the lignocaine group (24%).
  • The differences in outcomes between the two groups were statistically significant.

Conclusions:

  • Sevoflurane administration prior to extubation significantly reduces coughing and desaturation in pediatric patients under six years old.
  • This suggests sevoflurane is a more effective agent for preventing post-extubation respiratory events in this age group.
  • The findings support the use of sevoflurane for improved patient safety during emergence from anesthesia.
Abstract

Keywords:
Intravenous lignocaine (IV)LaryngospasmPost extubationSevoflurane

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