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Relationship Of Lipids, C-Reactive Protein And Sialic Acid In The Healthy Individuals

Mohammad Israr1, Chaman Gul2, Aziz Ur Rehman3

  • 1Department of Biochemistry, Bacha Khan Medical College, Mardan, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|June 26, 2018
PubMed

Insights

High cholesterol and triglycerides are risk factors for atherosclerosis. This study found C-reactive protein (CRP) and Sialic Acid levels correlate with lipid profiles, suggesting their potential as atherosclerotic disease predictors.

Area of Science:

  • Biochemistry
  • Cardiovascular Health
  • Inflammatory Markers

Background:

  • Elevated cholesterol and triglycerides are key risk factors for atherosclerosis and coronary heart disease.
  • C-reactive protein (CRP) and Sialic Acid levels rise during inflammatory conditions.
  • Understanding these markers in healthy individuals is crucial for disease prediction.

Purpose of the Study:

  • To investigate serum lipid profiles, CRP, and Sialic Acid levels in healthy individuals.
  • To determine the interrelationships between these biochemical markers.
  • To assess their potential as predictors of atherosclerotic disease.

Main Methods:

  • A cross-sectional study involving 200 healthy participants aged 18-50.
  • Analysis of serum lipid profile, CRP, and Sialic Acid using standardized methods.
  • Statistical analysis to identify correlations between measured parameters.

Main Results:

  • Simultaneous elevations in serum lipids, CRP, and Sialic Acid were more frequent in females.
  • CRP and Sialic Acid showed significant negative correlation with HDL.
  • Sialic Acid positively correlated with triglycerides; CRP correlated with total cholesterol and LDL.

Conclusions:

  • Serum CRP and Sialic Acid exhibit significant correlations with lipid profiles, including HDL, triglycerides, total cholesterol, and LDL.
  • Despite costs, CRP and Sialic Acid are valuable predictors for atherosclerotic disease.
  • These findings highlight the role of inflammation markers in cardiovascular risk assessment.
Abstract

Keywords:
CRPCholesterolHDLLDLSialic AcidTriglycerides

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