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Updated: Feb 8, 2026
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Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
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Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Feng Pan1, Jie Zhang2, Yuyan Liu3
1Department of Andrology, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital.
Journal of Visualized Experiments : Jove
|June 26, 2018
Summary
Intracavernosal pressure (ICP) recording in rats is a popular method to study erectile dysfunction (ED). This guide details the ICP recording procedure for accurate erectile function assessment in rodent research.
Area of Science:
- Physiology
- Urology
- Pharmacology
Background:
- Erectile dysfunction (ED) is a common male sexual disorder.
- Rodents are frequently used models for studying erectile function and dysfunction.
- Intracavernosal pressure (ICP) measurement is a key method for evaluating erectile function in rodents.
Purpose of the Study:
- To provide a detailed introduction to ICP recording in rats.
- To complement existing protocols for efficient and accurate erectile function assessment.
- To highlight the importance of ICP recording for understanding erectile physiology and pathology.
Main Methods:
- ICP is measured following electrical stimulation of the cavernous nerves (CNs) in rats.
- Mean arterial pressure (MAP) from the carotid artery serves as the reference for ICP.
- ICP response curves are analyzed to derive key erectile function parameters.
Main Results:
- ICP recording provides comprehensive data on erectile function parameters.
- This method is more informative than the apomorphine-induced penile erection test.
- ICP recording is more cost-effective than telemetric monitoring.
Conclusions:
- ICP recording is the most popular method for evaluating erectile function in rodents due to its informational yield and cost-effectiveness.
- Successful ICP recordings require meticulous attention to detail, practice, and strict adherence to the operational method.
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