Related Experiment Video
Updated: Feb 8, 2026

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station INBEST
Published on: April 23, 2015
Disease classification: from phenotypic similarity to integrative genomics and beyond
1Department of Biostatistics, Virginia Commonwealth University, 830 East Main Street, Richmond, VA, USA.
Abstract:
A fundamental challenge of modern biomedical research is understanding how diseases that are similar on the phenotypic level are similar on the molecular level. Integration of various genomic data sets with the traditionally used phenotypic disease similarity revealed novel genetic and molecular mechanisms and blurred the distinction between monogenic (Mendelian) and complex diseases. Network-based medicine has emerged as a complementary approach for identifying disease-causing genes, genetic mediators, disruptions in the underlying cellular functions and for drug repositioning. The recent development of machine and deep learning methods allow for leveraging real-life information about diseases to refine genetic and phenotypic disease relationships. This review describes the historical development and recent methodological advancements for studying disease classification (nosology).
More Related Videos
Related Concept Videos
Causes of Similarity-Dissimilarity Effect
Genomics
Factors Influencing Attraction III: Similarity
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Force Classification
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
Classification of Neurotransmitters

