Related Experiment Video

Updated: Feb 8, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

419

Newly Diagnosed Lung Cancer: Which Molecular Tests Are Needed for Optimal Treatment Decision Making?

Apar Kishor Ganti

    Oncology (Williston Park, N.Y.)
    |June 26, 2018
    PubMed

    Insights

    Testing advanced non-small-cell lung cancer (NSCLC) patients for molecular abnormalities is crucial for personalized treatment. Early molecular profiling guides the selection of targeted agents and checkpoint inhibitors for better outcomes.

    Area of Science:

    • Oncology
    • Molecular Pathology
    • Translational Medicine

    Background:

    • Advanced non-small-cell lung cancer (NSCLC) management has evolved significantly.
    • New understanding of molecular drivers and immune targets in NSCLC.
    • Availability of targeted agents and immune checkpoint inhibitors.

    Purpose of the Study:

    • To outline an approach for diagnostic evaluation of newly diagnosed advanced NSCLC.
    • To emphasize the importance of molecular testing in NSCLC.
    • To guide selection of optimal, personalized treatment strategies.

    Main Methods:

    • Review of current knowledge on NSCLC molecular basis and targeted therapies.
    • Proposal for a coordinated diagnostic evaluation process.
    • Integration of information from surgical pathology, molecular pathology, and medical oncology.

    Main Results:

    • Molecular profiling identifies actionable mutations and immune targets.
    • Timely testing enables prompt initiation of appropriate therapy.
    • Personalized treatment selection based on molecular abnormalities.

    Conclusions:

    • Comprehensive molecular testing is essential for advanced NSCLC patients.
    • Multidisciplinary collaboration is key for effective diagnostic evaluation.
    • Tailoring treatment based on molecular findings improves patient management.

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