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Related Concept Videos

Metallic Solids02:37

Metallic Solids

20.8K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.8K
Structures of Solids02:22

Structures of Solids

18.0K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
18.0K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Factors Affecting Solubility04:01

Factors Affecting Solubility

37.2K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.2K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.2K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K

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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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Krüppel-like factor 4 expression in solid tumor prognosis: A meta-analysis.

Miaomei Yu1, Bo Hao2, Yuxia Zhan1

  • 1Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 26, 2018
PubMed
Summary

Low Krüppel-like factor 4 (KLF4) expression is linked to poorer survival in solid tumors. This meta-analysis confirms KLF4 as a potential prognostic marker for cancer patients, highlighting its importance in predicting patient outcomes.

Keywords:
CancerCarcinomaKrüppel-like factor 4Meta-analysisPrognosisTumor

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Related Experiment Videos

Last Updated: Feb 8, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Krüppel-like factor 4 (KLF4) exhibits dual roles as a tumor suppressor or oncogene in various cancers.
  • The prognostic significance of KLF4 in human solid tumors remains debated.
  • This meta-analysis aims to clarify the prognostic value of KLF4 in solid tumors.

Purpose of the Study:

  • To systematically evaluate the prognostic value of Krüppel-like factor 4 (KLF4) in patients with solid tumors.
  • To determine if KLF4 expression levels can predict overall survival (OS) and disease-free survival (DFS).

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Embase, and Cochrane Library.
  • Hazard ratios (HRs) for OS and DFS were pooled using fixed-effects and random-effects models.
  • Meta-regression and subgroup analyses were employed to investigate heterogeneity, alongside publication bias assessments.

Main Results:

  • Twenty-two studies comprising 2988 patients were included in the analysis.
  • Low KLF4 expression was significantly associated with worse OS (HR = 1.71, P < 0.001) and DFS (HR = 1.74, P < 0.001).
  • These findings indicate that reduced KLF4 expression is an independent predictor of poor prognosis in solid cancers.

Conclusions:

  • Krüppel-like factor 4 (KLF4) demonstrates potential as a predictive biomarker for prognosis in solid cancer patients.
  • Low KLF4 expression serves as a significant indicator of adverse survival outcomes.