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Ultrasound-sensitive microrobotic sensor with robust anchoring for long-term digestive lesion assessment
Chen Xin1,2, Yuqiong Wang2, Yihang Jiang2
1Institute of Humanoid Robots, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China.
National Science Review
|May 25, 2026
Summary
This study introduces an ultrasound-sensitive microrobotic sensor for remote lesion assessment and drug delivery. The microrobotic sensor offers robust anchoring and wireless monitoring for digestive disease management.
Area of Science:
- Biomedical Engineering
- Robotics
- Medical Diagnostics
Background:
- Microrobots show promise in targeted drug delivery.
- Remote lesion assessment using microrobots remains a challenge.
Purpose of the Study:
- To design an ultrasound-sensitive microrobotic sensor (USMS) for wireless, long-term digestive disease treatment and assessment.
- To enable remote monitoring of lesion size and therapeutic efficacy.
Main Methods:
- Developed a bioinspired microneedle design for robust anchoring against fluid flow and peristaltic forces.
- Integrated dual magnetic and focused ultrasound actuation for locomotion and drug delivery.
- Incorporated an air cavity for strong ultrasound reflection, enabling remote sensing.
Main Results:
- The USMS demonstrated stable anchoring under significant fluid flow (402 mm/s) and peristaltic forces (66.5 mN).
- Achieved reliable on-demand drug delivery and lesion size sensing in mouse models.
- The air cavity design facilitated remote, long-term sensing of lesion radius.
Conclusions:
- The USMS is a versatile robotic platform for digestive disease treatment and assessment.
- It offers potential for monitoring lesion evolution in clinical settings.
- This technology advances remote sensing capabilities in microrobotics.
