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Polymers02:34

Polymers

41.1K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymers02:34

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Factors Affecting Solubility04:01

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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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Solubility Equilibria03:07

Solubility Equilibria

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Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
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Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

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Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
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Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

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Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
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Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
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Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics

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Model Protein Adsorption on Polymers Explained by Hansen Solubility Parameters.

Liang Fang1, Ranjana Singh1, Lloyd Waxman1

  • 1Scientific Insights Lab, West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, Pennsylvania 19341.

Journal of Pharmaceutical Sciences
|June 26, 2018
PubMed
Summary
This summary is machine-generated.

Hansen solubility parameters (HSP) theory successfully explains bovine serum albumin (BSA) protein adsorption on polymer surfaces. Adsorbed BSA proteins become more hydrophobic, indicating partial denaturation, which HSP can predict.

Keywords:
Hansen solubility parametersbovine serum albumin (BSA)contact anglecyclic olefin polymerfluorescence microscopyglasspolymer surfaceprotein adsorptionsilicone

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Area of Science:

  • Materials Science
  • Biophysics
  • Polymer Science

Background:

  • Hansen solubility parameters (HSP) are established for predicting solvent-polymer interactions and polymer miscibility.
  • Understanding protein adsorption on surfaces is crucial for biomaterials and biomedical applications.

Purpose of the Study:

  • To investigate the applicability of HSP theory in explaining bovine serum albumin (BSA) protein adsorption onto various polymer surfaces.
  • To determine if HSP can predict the extent of protein adsorption and characterize the state of adsorbed proteins.

Main Methods:

  • Utilized Hansen solubility parameters (HSP) to model protein-surface interactions.
  • Analyzed protein adsorption data to calculate the HSP of adsorbed BSA.
  • Compared the HSP of native BSA with that of adsorbed BSA.

Main Results:

  • HSP theory successfully explains the amount of BSA protein adsorption on different polymer surfaces.
  • The calculated HSP of adsorbed BSA proteins differed from native BSA, indicating increased hydrophobicity.
  • Adsorbed BSA proteins exhibit partial denaturation, exposing hydrophobic regions.

Conclusions:

  • HSP provides a theoretical framework to understand and predict BSA protein adsorption on solid surfaces.
  • The increased hydrophobicity of adsorbed BSA suggests a denaturation process upon surface interaction.
  • This HSP-based model can guide the selection of materials with minimal protein adsorption for biological applications.