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Updated: Feb 8, 2026

Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains
Published on: November 6, 2017
Next Time, Save Mushrooms for the Pizza!
1Research and Development Service, VA Maryland Health Care System, Baltimore, Maryland, USA; Departments of Dermatology and Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abstract:
Mann et al. (2018) use recombinant human tyrosinase to screen for novel inhibitors of pigmentation. They develop thiamidol, a new thiazolyl-resorcinol derivative, that is a submicromolar tyrosinase inhibitor and effective for treating solar lentigines. Thiamidol and established inhibitors of pigmentation exhibit substantially different activities on human and mushroom tyrosinase, supporting use of the human enzyme in high-throughput screens.
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