Pelvic Exenteration for Recurrent and Persistent Cervical Cancer.

Area of Science:

• Gynecologic Oncology
• Surgical Oncology
• Cancer Research

Background:

• Pelvic exenteration (PE) is a complex surgical procedure for advanced cervical cancer.
• Limited data exists on PE outcomes from China, necessitating institutional experience sharing.
• Previous studies indicate PE can achieve favorable survival, but prognostic factors require further elucidation.

Purpose of the Study:

• To report the single-institution experience with pelvic exenteration for cervical cancer in China.
• To identify prognostic factors influencing survival outcomes after PE.
• To evaluate the feasibility and safety of PE in this patient cohort.

Main Methods:

• Retrospective analysis of 38 patients undergoing PE for recurrent or persistent cervical cancer (Jan 2009-Jan 2017).
• Inclusion of epidemiological and clinicopathological data for survival analysis.
• Univariate and Cox regression analyses to determine independent prognostic factors for overall survival (OS) and disease-free survival (DFS).

Main Results:

• The median age was 45 years; 31 patients had recurrent and 7 had persistent disease.
• Overall complication rates were 55.3% early and 39.5% late; 5.3% perioperative mortality.
• Five-year OS and DFS rates were 48% and 40%, respectively. Margin and mesorectal lymph node status were independent predictors of survival.

Conclusions:

• Pelvic exenteration can achieve favorable survival outcomes in selected patients with recurrent or persistent cervical cancer.
• Surgical margins and lymph node status are critical factors for successful PE outcomes.
• This study provides valuable insights into PE for cervical cancer in the Chinese population.