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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
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Multifocality is associated with central neck lymph node metastases in papillary thyroid microcarcinoma
Weihui Zheng1, Kejing Wang1, Junzhou Wu2
1Department of Head & Neck Surgery Zhejiang Cancer Hospital and Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, People's Republic of China.
Cancer Management and Research
|June 27, 2018
Summary
Multifocality, especially with three or more foci, predicts central lymph node metastasis in papillary thyroid microcarcinoma. This finding aids in identifying high-risk patients for prophylactic central neck lymph node dissection.
Area of Science:
- Endocrinology
- Oncology
- Surgical Pathology
Background:
- Papillary thyroid microcarcinoma (PTMC) risk stratification is crucial.
- Identifying predictors for central lymph node metastasis (CLNM) is essential for treatment planning.
Purpose of the Study:
- To evaluate multifocality as a predictive factor for CLNM in PTMC.
- To identify patients at high risk for CLNM.
Main Methods:
- Retrospective analysis of PTMC patients undergoing thyroidectomy and lymph node dissection.
- Multivariate analysis to determine independent predictors of CLNM.
Main Results:
- Multifocality, age, sex, tumor size, extrathyroidal extension, and nodular goiter were associated with CLNM.
- Multifocality independently predicted CLNM.
- Odds ratio for CLNM was 2.978 for patients with ≥3 tumor foci (P<0.001).
Conclusions:
- Multifocality with ≥3 foci is an independent predictor of CLNM in PTMC.
- Assessment of multifocality is recommended for selecting patients for prophylactic central neck lymph node dissection.
- Patients with multifocality may benefit from more radical treatment approaches.
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