Creating a database of internet-based clinical trials to support a public-led research programme: A descriptive...

Area of Science:

• Digital Health
• Clinical Research Methodology
• Public Health Interventions

Background:

• The proliferation of online trials presents both opportunities and challenges in research.
• The International Network for Knowledge on Well-being (ThinkWell™) promotes public and patient engagement in research using technology.

Purpose of the Study:

• To establish a baseline understanding of the online trial landscape.
• To quantify the use of internet-based technologies in trials.
• To analyze the evolution and application of these technologies over time.

Main Methods:

• Comprehensive search of bibliographic databases up to March 2015.
• Inclusion/exclusion criteria screening and data mapping.
• Iterative thematic analysis of identified studies.

Main Results:

• 1992 internet-based trials were identified by March 2015, showing substantial growth.
• The USA led in trial conduct, followed by the Netherlands and Australia.
• Interventions focused on obesity, smoking cessation, alcohol abuse, physical activity, depression, anxiety, and self-management/monitoring.

Conclusions:

• Confirmed a significant increase in internet use within clinical trials.
• Identified key themes and the need for further research.
• Aims to improve trial design, recruitment, and create an open-access resource for public-led research.