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Updated: Feb 8, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
ST elevation: Differential diagnosis and caveats. A comprehensive review to help distinguish ST elevation myocardial
1Jessa Hospital/Heart Centre Hasselt, Hasselt, Belgium.
Insights
Prompt electrocardiogram (ECG) diagnosis of ST segment elevation myocardial infarction (STEMI) is crucial for timely treatment. This review highlights non-ischemic ECG findings that mimic STEMI, preventing misdiagnosis and improving patient outcomes.
Area of Science:
- Cardiology
- Electrocardiography
- Emergency Medicine
Background:
- Acute ST segment elevation myocardial infarction (STEMI) requires urgent revascularization.
- Conditions mimicking STEMI on ECG may lead to inappropriate interventions.
- Accurate ECG interpretation is vital for differentiating ischemic from non-ischemic causes.
Purpose of the Study:
- To review ECG features of non-ischemic conditions that mimic STEMI.
- To aid clinicians in early recognition and prevention of misdiagnosis.
- To improve treatment strategies for patients with ST segment elevation on ECG.
Main Methods:
- Narrative clinical review of existing literature.
- Focus on ECG characteristics of various non-ischemic ST elevation mimics.
- Discussion of differential diagnostic criteria.
Main Results:
- Identified key ECG patterns distinguishing non-ischemic mimics from true STEMI.
- Highlighted conditions such as pericarditis, early repolarization, and Brugada syndrome.
- Emphasized the importance of clinical context in ECG interpretation.
Conclusions:
- Distinguishing non-ischemic ST elevation from STEMI on ECG is critical.
- Understanding mimics prevents unnecessary invasive procedures.
- Accurate diagnosis improves patient management and outcomes.
Abstract:
Prompt diagnosis of acute ST segment elevation myocardial infarction (STEMI) by the initial ECG is important in order to perform an urgent coronary angiography as soon as possible and achieve successful revascularization, therewith improving mortality and morbidity. Several diseases and conditions can mimic an acute myocardial infarction (AMI) but may not benefit from a (percutaneous) revascularization strategy. This narrative clinical review will discuss the ECG features of some of the causes of non-ischemic ST segment elevation to facilitate early recognition, prevent wrongful diagnosis and improve treatment outcomes.
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