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[Molecular mechanisms underlying daptomycin resistance]

Guojian Liao1, Xixi Peng1, Jun Tian1

  • 1Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|June 27, 2018
PubMed

Insights

Daptomycin resistance is rising in Gram-positive pathogens. This paper details how changes in cell wall and membrane metabolism contribute to daptomycin resistance in bacteria like Staphylococcus aureus and Enterococci.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Daptomycin is a critical antibiotic for treating serious Gram-positive bacterial infections.
  • Increasing daptomycin resistance poses a significant threat to public health.
  • Mechanisms of resistance involve alterations in bacterial cell wall and membrane processes.

Purpose of the Study:

  • To elucidate the unique mechanisms of daptomycin resistance in key pathogens.
  • To provide insights into the molecular basis of emerging daptomycin resistance.

Main Methods:

  • Review of existing literature on daptomycin resistance mechanisms.
  • Analysis of studies focusing on Staphylococcus aureus and Enterococci resistance.

Main Results:

  • Daptomycin resistance is linked to disruptions in cell wall homeostasis.
  • Alterations in membrane phospholipid metabolism are crucial for resistance.
  • Specific resistance pathways identified in Staphylococcus aureus and Enterococci.

Conclusions:

  • Understanding daptomycin resistance mechanisms is vital for developing new therapeutic strategies.
  • Targeting cell wall and membrane pathways may overcome resistance.
  • Continued surveillance of daptomycin resistance is essential.
Keywords:
cell wall homeostasisdaptomycindrug resistancephospholipid metabolism

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