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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
Published on: July 14, 2016
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Effects of Deep Brain Stimulation on Eye Movements and Vestibular Function
Aasef G Shaikh1,2, Chrystalina Antoniades3, James Fitzgerald3,4
1Department of Neurology, University Hospitals, Case Western Reserve University, Cleveland, OH, United States.
Frontiers in Neurology
|June 28, 2018
Summary
Deep brain stimulation (DBS) modulates basal ganglia circuits, impacting movement disorders. This review explores DBS effects on eye movements and vestibular function, offering insights into motor control and brain interactions.
Area of Science:
- Neuroscience
- Neurology
- Ophthalmology
Background:
- Deep brain stimulation (DBS) is a breakthrough for movement disorders.
- Basal ganglia circuits are key to motor control.
- The impact of DBS on ocular motor and vestibular functions is less explored.
Purpose of the Study:
- To review the influence of DBS on ocular motor and vestibular functions.
- To understand how basal ganglia stimulation affects eye movements in motor and cognitive domains.
- To provide guidance for optimizing DBS programming for motor outcomes.
Main Methods:
- Review of existing literature on DBS, basal ganglia, and ocular motor/vestibular function.
- Discussion of basal ganglia anatomy and physiology relevant to DBS.
- Analysis of baseline ocular motor deficits in Parkinson's disease and DBS effects.
Main Results:
- DBS influences ocular motor and vestibular functions.
- Understanding these effects aids in interpreting DBS impact on broader motor functions.
- Baseline deficits in Parkinson's disease are altered by DBS.
Conclusions:
- DBS of the basal ganglia, including globus pallidus, subthalamic nucleus, and thalamus, impacts ocular motor and vestibular systems.
- This review highlights the clinical and scientific importance of studying DBS effects on eye movements.
- Further research can optimize DBS therapy and enhance understanding of basal ganglia function.
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