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Diffuse Large B-cell Lymphoma Occurring with Rhinophyma: A Case Report.

Samuel Shatkin1, Michael Shatkin2, Katherine Smith3

  • 1Department of Plastic Surgery, Aesthetic Associates Centre, Buffalo, USA.

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|June 28, 2018
PubMed
Summary
This summary is machine-generated.

Rhinophyma, a severe acne rosacea stage, can mask underlying cancers. This case highlights a patient with rhinophyma who also had diffuse large B-cell lymphoma, emphasizing the need for vigilant diagnosis.

Keywords:
basal cell carcinomadiffuse large b-cell lymphomadlbcllymphomareconstructionrhinophymarosacea

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Rhinophyma is the advanced stage of acne rosacea, characterized by nasal disfigurement.
  • Typical rhinophyma presentation includes bulbous enlargement, erythema, and telangiectasia.
  • The characteristic appearance can sometimes lead to overlooking concurrent malignancies.

Observation:

  • A case of diffuse large B-cell lymphoma (DLBCL) occurring simultaneously with significant rhinophyma is presented.
  • The patient exhibited a classic disfiguring nasal appearance due to rhinophyma.
  • Non-typical changes within the rhinophymatous lesion or adjacent nasal areas were noted.

Findings:

  • A synchronous occurrence of DLBCL and marked rhinophyma was diagnosed.
  • Surgical intervention included wide local excision of the malignancy and reconstruction with forehead flaps.
  • Rhinophyma was managed with skin grafting and cheek flaps, followed by chemotherapy for systemic disease.

Implications:

  • This case underscores the critical need for thorough clinical evaluation in diagnosing and treating rhinophyma.
  • Physicians must maintain a high index of suspicion for malignancy in patients with atypical rhinophyma presentations.
  • Early detection and management of coexisting conditions are vital for improved patient outcomes.