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Related Experiment Video

Updated: Feb 8, 2026

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
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Does Prophylactic Ibuprofen After Surgical Atrial Septal Defect Repair Decrease the Rate of Post-Pericardiotomy

Edon J Rabinowitz1, David B Meyer2, Priya Kholwadwala3

  • 1Division of Pediatric Cardiology, Cohen Children's Medical Center of New York, Hofstra Northwell School of Medicine, 269-01 76th Ave, New Hyde Park, NY, 11040, USA. ERabinowitz@northwell.edu.

Pediatric Cardiology
|June 28, 2018
PubMed
Summary

Prophylactic ibuprofen did not reduce post-pericardiotomy syndrome (PPS) after surgical atrial septal defect (ASD) closure. This study found no difference in PPS incidence between patients who received ibuprofen and those who did not.

Keywords:
Atrial septal defectIbuprofenNon-steroidal anti-inflammatory drugsPost-cardiac injury syndromePost-pericardiotomy syndrome

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Area of Science:

  • Cardiology
  • Thoracic Surgery
  • Pediatric Cardiology

Background:

  • Post-pericardiotomy syndrome (PPS) is an inflammatory complication following cardiothoracic surgery.
  • Surgical atrial septal defect (ASD) closure has a higher incidence of PPS compared to other procedures.
  • Current management includes NSAIDs, with some centers using prophylactic ibuprofen.

Purpose of the Study:

  • To evaluate the impact of prophylactic ibuprofen on PPS development and severity after surgical ASD closure.
  • To specifically analyze outcomes in secundum-type ASD repairs.
  • To determine if ibuprofen prophylaxis alters PPS incidence in this patient population.

Main Methods:

  • Retrospective review of 207 surgical ASD repairs (2007-2017).
  • ASDs categorized by subtype.
  • PPS diagnosis confirmed by cardiologist documentation of clinical signs post-operatively.

Main Results:

  • Overall PPS incidence was 10% in the cohort.
  • No significant difference in PPS incidence was observed between patients receiving prophylactic ibuprofen and those who did not (P=1.0).
  • Four patients required pericardiocentesis; none received prophylactic ibuprofen.

Conclusions:

  • Prophylactic ibuprofen administration following surgical ASD repair did not decrease the incidence of post-pericardiotomy syndrome.
  • The findings suggest ibuprofen prophylaxis is not effective in preventing PPS in this surgical context.
  • Further research may explore alternative prophylactic strategies for PPS after ASD repair.