Related Experiment Video
Updated: Feb 8, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Colloidal stability of superparamagnetic iron oxide nanoparticles in the central nervous system: a review
Pierre-Olivier Champagne1,2, Harrison Westwick2, Alain Bouthillier2
1Polystim Neurotech Laboratory, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, H3T 1J4, Canada.
Abstract:
Superparamagnetic iron oxide nanoparticles (SPIONs) consist of nanosized metallic-based particles with unique magnetic properties. Their potential in both diagnostic and therapeutic applications in the CNS is at the source of an expanding body of the literature in recent years. Colloidal stability of nanoparticles represents their ability to resist aggregation and is a central aspect for the use of SPION in biological environment such as the CNS. This review gives a comprehensive update of the recent developments and knowledge on the determinants of colloidal stability of SPIONs in the CNS. Factors leading to aggregate formation and the repercussions of colloidal instability of SPION are reviewed in detail pertaining to their use in the CNS.
More Related Videos
Related Concept Videos
Colloids
What is a Nervous System?
Nuclear Stability
To hold positively charged protons together...
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
The Parasympathetic Nervous System

