Possible SAMe-induced mania
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Updated: Feb 8, 2026

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
Published on: July 29, 2012
Hesitha Abeysundera1, Ramandeep Gill2
1Psychiatry, Queensland Health, Cairns, Queensland, Australia.
Abstract:
This paper describes a patient who presented with mania with psychotic features in the context of concomitant use of S-adenosyl-L-methionine (SAMe) and selective serotonin reuptake inhibitor (SSRI). The aim of this case report is to provide medical practitioners with a greater awareness of the possibility of a psychotic episode and/or mania manifesting with concurrent use of SAMe and SSRI.
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