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Possible SAMe-induced mania
Hesitha Abeysundera1, Ramandeep Gill2
1Psychiatry, Queensland Health, Cairns, Queensland, Australia.
BMJ Case Reports
|June 29, 2018
Summary
Concurrent use of S-adenosyl-L-methionine (SAMe) and selective serotonin reuptake inhibitors (SSRIs) may trigger mania with psychotic features. This case report highlights the potential for serious psychiatric events when combining these substances.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- S-adenosyl-L-methionine (SAMe) is a popular dietary supplement.
- Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressants.
- The interaction between SAMe and SSRIs is not fully understood.
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