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Related Experiment Video

Updated: Feb 8, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Food allergy and anaphylaxis.

David Yue1, Amanda Ciccolini1, Ernie Avilla1

  • 1Division of Clinical Immunology & Allergy, Department of Medicine, Health Sciences Centre, McMaster University, Hamilton, ON, Canada.

Journal of Asthma and Allergy
|June 29, 2018
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Anaphylaxis, a severe allergic reaction often triggered by food, requires prompt epinephrine treatment. Management includes allergen avoidance and emerging immunotherapy for food allergies.

Keywords:
allergic reactionavoidanceepinephrinefoodimmunotherapytrigger

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Area of Science:

  • Immunology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Anaphylaxis is a critical, potentially fatal allergic reaction with diverse triggers.
  • Food allergy is the primary cause of anaphylaxis in children.
  • Reactions can be IgE-mediated, non-IgE-mediated, or nonimmunologic, influenced by cofactors.

Purpose of the Study:

  • To review anaphylaxis, emphasizing food allergy as a major cause.
  • To discuss the mechanisms, clinical presentation, diagnosis, and management of food-induced anaphylaxis.

Main Methods:

  • Literature review focusing on food allergy and anaphylaxis.
  • Analysis of IgE-mediated and non-IgE-mediated mechanisms.
  • Examination of diagnostic criteria and treatment strategies.

Main Results:

  • Food allergy is the leading cause of anaphylaxis in pediatric populations.
  • Clinical signs are varied, affecting multiple organ systems.
  • Epinephrine is the primary treatment, with allergen avoidance and immunotherapy as long-term strategies.

Conclusions:

  • Accurate diagnosis of food-induced anaphylaxis relies on clinical presentation and allergen identification.
  • Effective management necessitates prompt epinephrine administration and long-term allergen avoidance.
  • Food desensitization through immunotherapy represents a novel approach to managing food allergies.