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Updated: Feb 8, 2026
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
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Current perspectives on Mohs micrographic surgery for melanoma
Derek Beaulieu1, Ramin Fathi2, Divya Srivastava2
1Tufts University School of Medicine, Boston, MA.
Clinical, Cosmetic and Investigational Dermatology
|June 29, 2018
Summary
Mohs micrographic surgery (MMS) offers precise skin cancer removal with excellent margin control. Advances in staining techniques are increasing its acceptance for treating melanoma, showing promising results.
Area of Science:
- Dermatology
- Surgical Oncology
Background:
- Mohs micrographic surgery (MMS) is a tissue-sparing technique for skin cancer with optimal margin control.
- Widespread acceptance of MMS for malignant melanoma (MM) and melanoma in situ (MIS) lags behind its use for keratinocyte carcinomas, despite evidence of comparable or superior cure rates.
Purpose of the Study:
- To describe the performance of MMS for cutaneous melanoma.
- To discuss the rationale and evidence supporting MMS for MM and MIS.
- To review immunohistochemical stains and future directions for MMS in melanoma treatment.
Main Methods:
- Review of current literature and evidence regarding MMS for melanoma.
- Description of the MMS procedure for melanoma specimens.
- Discussion of immunohistochemical staining advancements in MMS.
Main Results:
- Immunohistochemical staining advances significantly improve the interpretation of MMS frozen sections for melanoma.
- Professional organizations increasingly recognize the utility of MMS for MM and MIS.
- Recent years have seen a rise in MMS utilization for cutaneous melanoma.
Conclusions:
- MMS is an expanding and effective treatment option for cutaneous melanoma.
- Advances in immunohistochemistry enhance the safety and efficacy of MMS for melanoma.
- Further research and adoption of MMS for melanoma are warranted.
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