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Updated: Feb 8, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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V(D)J Rearrangement Is Dispensable for Producing CDR-H3 Sequence Diversity in a Gene Converting Species.

Philip A Leighton1, Jacqueline Morales1, William D Harriman1

  • 1Ligand Pharmaceuticals, Emeryville, CA, United States.

Frontiers in Immunology
|June 29, 2018
PubMed
Summary

Chicken antibody repertoires rely on a single framework, with diversity generated by gene conversion and somatic hypermutation. This study compares diversity from gene conversion alone versus V(D)J rearrangement plus gene conversion.

Keywords:
CDR-H3 repertoireV(D)J rearrangementgene conversionhuman monoclonal antibodiessomatic hypermutationtransgenic chickens

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