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A novel IBV Lineage within Genotype GVII (GVII-2) Representing a Unique Serotype Circulating in Chicken Flocks in
Bing Wang1, Xiaona Zhang1, Zongxi Han1
1Division of Avian Infectious Diseases, State Key Laboratory for Animal Disease Prevention and Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, People's Republic of China.
Avian Diseases
|July 13, 2026
Summary
A new infectious bronchitis virus (IBV) lineage, GVII-2, has been identified in China. This novel IBV strain exhibits unique genetic characteristics and causes significant pathogenicity in chickens, including kidney and oviduct issues.
Area of Science:
- Veterinary Virology
- Avian Pathology
- Molecular Epidemiology
Background:
- Infectious Bronchitis Virus (IBV) is a significant pathogen in poultry worldwide.
- Continuous evolution and emergence of novel IBV genotypes pose challenges for disease control.
Purpose of the Study:
- To report the detection and characterization of a novel IBV lineage (GVII-2) in China.
- To investigate the genetic diversity, genomic features, and pathogenicity of this new IBV strain.
Main Methods:
- Virus isolation and sequencing of S1 genes and complete genomes.
- Phylogenetic analysis to determine genetic relationships.
- Pathogenicity studies in specific-pathogen-free (SPF) chickens.
Main Results:
- A novel IBV lineage, GVII-2, was detected in commercial chicken flocks in China since 2008.
- Genomic analysis revealed recombination events, with a backbone from GI-19 and distinct S, 3a, and 5a genes.
- The GVII-2 strain demonstrated significant tropism for kidneys and reproductive organs, causing cystic oviduct formation in chickens.
Conclusions:
- The GVII-2 lineage represents a distinct serotype and a potential threat to the poultry industry.
- Understanding the genetic makeup and pathogenicity of novel IBV strains is crucial for developing effective vaccines and control strategies.
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