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Immunotherapy in the Asiatic population: any differences from Caucasian population?
Lunxi Peng1,2, Yi-Long Wu1,2
1Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Journal of Thoracic Disease
|June 29, 2018
Summary
The immunotherapy age is here, but more research is needed on immune checkpoint inhibitors (CPI) for Asian patients with non-small cell lung cancer (NSCLC). Ethnic differences in EGFR mutations and hepatitis B may impact treatment outcomes.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Immune checkpoint inhibitors (CPI) offer clinical benefits for advanced non-small cell lung cancer (NSCLC).
- Limited clinical trial evidence exists for immunotherapy in Asian populations.
- Ethnic variations in targeted therapies suggest potential differences in immunotherapies.
Purpose of the Study:
- To review potential ethnic differences in immunotherapy efficacy and toxicity between Caucasian and Asian populations.
- To identify factors contributing to these ethnic disparities in non-small cell lung cancer (NSCLC) patients.
Main Methods:
- Literature review focusing on clinical trials and genetic/virological factors in non-small cell lung cancer (NSCLC) patients.
- Comparative analysis of immunotherapy outcomes across different ethnic groups.
Main Results:
- Asian patients exhibit a higher proportion of EGFR mutations compared to Caucasian patients.
- Hepatitis B virus (HBV) infection is more prevalent in Asian populations.
- Unexpected immune-related toxicities have been observed in Asian patients undergoing immunotherapy.
Conclusions:
- Ethnic differences, including EGFR mutation rates and HBV infection, may influence immunotherapy outcomes in non-small cell lung cancer (NSCLC).
- Further research is crucial to understand and address these disparities for optimal immunotherapy application in Asian patients.
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