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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
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Staphylococcus aureus Myocarditis with Associated Left Ventricular Apical Thrombus
Michael McGee1, Emily Shiel2, Stephen Brienesse1,3
1Cardiovascular Department, John Hunter Hospital, Lookout Road, New Lambton Heights, NSW 2305, Australia.
Case Reports in Cardiology
|June 29, 2018
Summary
Staphylococcus aureus myocarditis, though rare and often fatal, can be successfully treated. This case highlights effective management of Staphylococcus aureus myocarditis with antibiotics and anticoagulation, leading to complete recovery.
Area of Science:
- Cardiology
- Infectious Diseases
- Immunology
Background:
- Staphylococcus aureus myocarditis is a rare condition with high mortality, typically affecting immunocompromised individuals.
- Methotrexate for rheumatoid arthritis can increase susceptibility to severe infections.
Observation:
- A 44-year-old man on methotrexate presented with septic shock and was diagnosed with Staphylococcus aureus myocarditis.
- Echocardiogram and cardiac MRI revealed endomyocardial edema and a left ventricular apical thrombus with preserved systolic function.
Findings:
- Cardiac MRI confirmed acute myocarditis with an apical mural thrombus.
- Treatment with intravenous antibiotics and apixaban led to complete resolution of edema and thrombus.
- Repeat CMR showed significant improvement in endomyocardial edema and thrombus resolution.
Implications:
- This case demonstrates that Staphylococcus aureus myocarditis, even in an immunocompromised patient, is treatable.
- Successful management involves prompt diagnosis, antibiotics, and anticoagulation.
- Early imaging and follow-up are crucial for monitoring recovery from myocarditis and associated thrombus.
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