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Updated: Feb 8, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
A ruthenium-platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression
Swapan S Jain1, Craig M Anderson1, Iden A Sapse1
1Department of Chemistry, Bard College, 30 Campus Road, Annandale-on-Hudson, New York 12504, USA. sjain@bard.edu.
Abstract:
IT127 is a dinuclear transition metal complex that contains a Pt(ii) and a Ru(iii) metal center. We have shown that IT127 is significantly more effective in binding the 29-base sarcin ricin loop (SRL) RNA in comparison to Cisplatin, a hallmark anticancer agent. Binding site analysis shows that IT127 prefers purine bases and the GAGA tetraloop region of SRL RNA. Our results with a dihydrofolate reductase (DHFR) model system reveal that IT127 binding to mRNA reduces translation of DHFR enzyme and that the Ru(iii) and Pt(ii) centers in IT127 appear to work in a synergistic manner.
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