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A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
An Immobilized-Dirhodium Hollow-Fiber Flow Reactor for Scalable and Sustainable C-H Functionalization in Continuous
Chun-Jae Yoo1, Daniel Rackl2, Wenbin Liu2
1School of Chemical & Biomolecular Engineering Department, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA, 30332, USA.
Abstract:
A scalable flow reactor is demonstrated for enantioselective and regioselective rhodium carbene reactions (cyclopropanation and C-H functionalization) by developing cascade reaction methods employing a microfluidic flow reactor system containing immobilized dirhodium catalysts in conjunction with the flow synthesis of diazo compounds. This allows the utilization of the energetic diazo compounds in a safe manner and the recycling of the dirhodium catalysts multiple times. This approach is amenable to application in a bulk-scale synthesis employing asymmetric C-H functionalization by stacking multiple fibers in one reactor module. The products from this sequential flow-flow reactor are compared with a conventional batch reactor or flow-batch reactor in terms of yield, regioselectivity, and enantioselectivity.
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Flow Sheet
Here's a closer look at the examples of flowsheets commonly used by nurses:
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