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Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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G-protein Coupled Receptors01:21

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Corrigendum: Quantifying the cooperative subunit action in a multimeric membrane receptor.

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    This summary is machine-generated.

    This article corrects a previously published Digital Object Identifier (DOI). The correct DOI ensures proper citation and retrieval of the scientific research article for accurate referencing and access.

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    Area of Science:

    • Scientific publishing
    • Digital Object Identifier (DOI) systems

    Context:

    • Ensuring accurate referencing in scientific literature is crucial for research integrity.
    • Digital Object Identifiers (DOIs) are essential for persistent and reliable access to scholarly articles.

    Purpose:

    • To provide the correct Digital Object Identifier (DOI) for a specific scientific article.
    • To rectify an error in the previous citation, ensuring accurate tracking and retrieval of the research.

    Summary:

    • This communication serves to correct the Digital Object Identifier (DOI) associated with a scientific publication.
    • The correction ensures that readers and indexing services can accurately locate and access the intended research article.

    Impact:

    • Improved discoverability and accessibility of the scientific research.
    • Enhanced integrity of scientific record-keeping and citation practices.
    • Facilitates accurate citation by researchers, preventing misattribution or access issues.