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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Related Experiment Video

Updated: Feb 8, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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DDR1 and DDR2 in skin.

Muriel Cario1

  • 1a INSERM 1035 , University Bordeaux , Bordeaux , France.

Cell Adhesion & Migration
|June 29, 2018
PubMed
Summary

The study reveals distinct roles for DDR1 and DDR2 in skin health and disease. Targeting these discoidin domain receptors (DDRs) offers therapeutic potential but requires careful management of side effects.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Cell Biology

Background:

  • Discoidin domain receptors (DDR1 and DDR2) are expressed in various skin compartments, including the epidermis, dermis, and hypodermis.
  • Their expression patterns vary based on cellular embryonic origin and skin layer.
  • Differential expression of DDR1 and DDR2 is observed in physiological and pathological skin processes.

Purpose of the Study:

  • To investigate the distinct roles of DDR1 and DDR2 in different skin compartments.
  • To understand the differential involvement of DDR1 and DDR2 in skin homeostasis, wound healing, and diseases like melanoma and systemic sclerosis.
  • To evaluate the therapeutic potential of targeting DDRs in skin conditions.

Main Methods:

  • Analysis of DDR1 and DDR2 expression in different skin compartments (epidermis, dermis, hypodermis).
Keywords:
CCN3Melanocytecadherincell adhesive proteinsfibroblastintegrinskeratinocyte

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  • Examination of DDR expression during physiological processes (e.g., wound healing).
  • Investigation of DDR dysregulation in pathological skin conditions (e.g., melanoma, systemic sclerosis, keloid formation).

    • Main Results:

    • DDR1 and DDR2 exhibit distinct expression profiles across skin layers and cell types.
    • In epidermis, DDR1 is crucial for melanocyte homeostasis, while DDR2 is implicated in melanoma.
    • In dermis, DDR2 is vital for normal wound healing, whereas DDR1 dysregulation is linked to abnormal healing and keloid formation.

    Conclusions:

    • DDR1 and DDR2 play compartment-specific roles in skin biology and pathology.
    • Dysregulation of a specific DDR can be associated with pathological processes, independent of its role in basal homeostasis.
    • Targeting DDRs presents a potential therapeutic strategy for skin diseases, but careful consideration of side effects is necessary.