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Delivering Phage Products to Combat Antibiotic Resistance in Developing Countries: Lessons Learned from the HIV/AIDS

Tobi E Nagel1

  • 1Phages for Global Health, 383 62nd Street, Oakland, CA 94618, USA. tobi@phagesforglobalhealth.org.

Viruses
|June 30, 2018
PubMed

Insights

Lessons from the HIV/AIDS epidemic, including developing antiretroviral drugs (ARVs), can guide the fight against antimicrobial resistance (AMR). Bacteriophages (phages) show promise as a new AMR therapeutic, but require global coordination and policy changes.

Area of Science:

  • Microbiology
  • Epidemiology
  • Drug Development

Background:

  • The antimicrobial resistance (AMR) crisis poses a significant global health threat, comparable to the historical impact of HIV/AIDS.
  • Both AMR and HIV/AIDS necessitate the development of novel therapeutic agents for effective disease control.

Purpose of the Study:

  • To examine parallels between the HIV/AIDS epidemic and the AMR crisis.
  • To explore how lessons learned from the development of antiretroviral drugs (ARVs) can inform the development of new antimicrobial therapies, specifically bacteriophages (phages).

Main Methods:

  • Comparative analysis of historical approaches to HIV/AIDS drug development.
  • Evaluation of bacteriophages (phages) as potential antimicrobial agents based on their characteristics and development trajectory.
  • Review of necessary international coordination and regulatory policy modifications.

Main Results:

  • Antimicrobial resistance (AMR) is projected to cause more deaths annually than HIV/AIDS did at its peak.
  • Bacteriophages (phages) offer advantages such as inexpensive manufacturing, rapid development, and inherent mechanisms to prevent resistance.
  • The development pathway for phage-based antimicrobials mirrors key stages observed in the progression of antiretroviral drugs (ARVs).

Conclusions:

  • Applying strategies from the antiretroviral drugs (ARVs) development to antimicrobial resistance (AMR) is a viable approach.
  • Bacteriophages (phages) represent a promising therapeutic avenue for combating antimicrobial resistance (AMR).
  • Successful broad application of phage-based therapies necessitates international collaboration and adaptive regulatory frameworks.
Keywords:
antibioticantimicrobial resistancebacteriophagedeveloping countriesglobal healthinfectious diseasephage therapy

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