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A Case of Congenital Complete Atrioventricular Block Treated with Transdermal Tulobuterol

Toshihiko Ikuta1, Kazumichi Fujioka1, Yumi Sato2

  • 1Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

The Kobe Journal of Medical Sciences
|June 30, 2018
PubMed

Insights

Congenital complete atrioventricular block (CCAVB) in newborns can cause intractable bradycardia. A transdermal tulobuterol patch successfully treated bradycardia, offering a potential alternative to pacemakers.

Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Pharmacology

Background:

  • Congenital complete atrioventricular block (CCAVB) necessitates permanent pacemaker implantation.
  • Postnatal medical therapy for bradycardia in CCAVB remains controversial.

Observation:

  • A newborn presented with CCAVB and intractable bradycardia.
  • The infant's condition did not respond to conventional treatments.

Findings:

  • Transdermal tulobuterol, a selective β2-adrenoceptor agonist, was administered.
  • Tulobuterol effectively managed the infant's bradycardia, demonstrating positive chronotropic effects.

Implications:

  • Transdermal tulobuterol may serve as an optional medical therapy for CCAVB.
  • This approach offers a potential alternative when pacemaker implantation is not feasible or immediately available.

Keywords:
congenital complete atrioventricular blocknewbornSS-A/Ro antibodiestulobuterol

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