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Published on: March 8, 2018
Second-generation antipsychotic use in borderline personality disorder: What are we targeting?
Adrian Wasylyshen1, Andrew M Williams2
1PharmD Candidate, Loma Linda University School of Pharmacy, Loma Linda, California.
Introduction:
Borderline personality disorder (BPD) is a personality disorder plagued with high rates of psychotropic polypharmacy. Estimates show that second-generation antipsychotics (SGAs) are used in most of these patients; however, they are being prescribed off label.
Methods:
A literature review was conducted via PubMed in search for studies evaluating SGA use in BPD.
Results:
There are available data investigating 8 of 11 SGAs and their use in BPD. Of N = 269 potential articles, N = 34 evaluating the use of SGAs in BPD were included.
Discussion:
Strong evidence supporting SGAs in BPD is lacking. Potential target symptoms in which a SGA may be useful include depression, anxiety, anger, impulsivity, and paranoia/dissociative behavior.
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