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Updated: Feb 8, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Priapism and renal colic in a patient treated with duloxetine
G Lucy Wilkening1, Shelly A Kucherer2, Antoine B Douaihy3
1Assistant Professor, Department of Pharmacy Practice, University of the Incarnate Word Feik School of Pharmacy, San Antonio, Texas, wilkenin@uiwtx.edu; Previously: Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center.
Abstract:
Antidepressant medications are associated with a variety of genitourinary and adverse sexual effects, such as urinary hesitation, priapism, and delayed ejaculation. Here, we report a case of priapism and renal colic following initiation of duloxetine in a patient with history of tolerated selective serotonin reuptake inhibitor treatment. To our knowledge, this represents the first report of priapism and renal colic associated with duloxetine use. This case contributes to the current body of evidence describing adverse genitourinary and sexual effects associated with antidepressant medications.
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