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Tubular aggregates: their association with myalgia
Journal of Neurology, Neurosurgery, and Psychiatry
|September 1, 1985
Summary
Tubular aggregates, identified in 0.6% of muscle biopsies, were strongly linked to myalgia. These aggregates, originating from the sarcoplasmic reticulum, may play a role in the development of muscle pain.
Area of Science:
- Neurology
- Pathology
- Muscle Biology
Background:
- Tubular aggregates are an ultrastructural finding in muscle.
- Their clinical significance, particularly in relation to myalgia, is not well-established.
Purpose of the Study:
- To investigate the prevalence of tubular aggregates in muscle biopsies.
- To determine the association between tubular aggregates and clinical symptomatology, specifically myalgia.
Main Methods:
- Retrospective review of 3,000 consecutive muscle biopsies.
- Correlation of the presence and abundance of tubular aggregates with patient clinical data.
Main Results:
- Tubular aggregates were found in 19 patients (0.6%).
- Twelve of these patients (63%) presented with severe myalgia.
- Abundant tubular aggregates were observed in patients with myalgia.
Conclusions:
- A significant association exists between tubular aggregates and myalgia.
- Tubular aggregates, originating from the sarcoplasmic reticulum, are implicated in the pathogenesis of myalgia.