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Current Designs of Polymer Blends in Solid Dispersions for Improving Drug Bioavailability
Phuong H L Tran1, Wei Duan1, Beom-Jin Lee2
1Deakin University, School of Medicine, Geelong, Australia.
Current Drug Metabolism
|June 30, 2018
Summary
Ternary solid dispersions enhance drug absorption and bioavailability by utilizing polymer blends. These formulations improve dissolution rates and maintain the drug's amorphous state, crucial for effective delivery.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Ternary solid dispersions are effective for improving drug absorption and bioavailability.
- Recent publications highlight the use of hydrophilic polymers combined with hydrophobic polymers.
Purpose of the Study:
- To provide a comprehensive review of ternary solid dispersions.
- To discuss the role of polymer blends in drug formulation.
Main Methods:
- Review of recent publications on polymer blends in solid dispersions.
- Discussion of polymer miscibility and its impact.
Main Results:
- Ternary solid dispersions improve dissolution rates.
- Second polymers inhibit crystal growth and maintain the amorphous state.
- Miscible polymer blends are key to formulation success.
Conclusions:
- Characterization techniques for solid dispersions and polymer miscibility are summarized.
- Ternary solid dispersions offer a promising approach for drug delivery enhancement.
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