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Updated: Feb 8, 2026
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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
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Macrophage CD31 Signaling in Dissecting Aortic Aneurysm
Francesco Andreata1, Varouna Syvannarath1, Marc Clement1
1INSERM U1148, DHU FIRE, Université Paris Diderot, PRES Sorbonne Paris Cité, Paris, France.
Journal of the American College of Cardiology
|June 30, 2018
Summary
A CD31 agonist peptide, P8RI, promotes macrophage repair and aids healing in experimental acute aortic dissection and intramural hematoma (ADIM) in mice. This suggests P8RI could be a potential therapeutic for ADIM.
Area of Science:
- Vascular Biology
- Immunology
- Regenerative Medicine
Background:
- Acute aortic dissection and intramural hematoma (ADIM) are characterized by inflammation.
- CD31 signaling plays a role in macrophage function during vascular injury.
Purpose of the Study:
- To evaluate the therapeutic potential of a drug-suitable CD31 agonist peptide (P8RI) in a mouse model of ADIM.
Main Methods:
- ApoE-/- mice received P8RI or vehicle after ADIM induction.
- Leukocyte analysis via flow cytometry.
- Histology and immunofluorescence assessed aortic healing.
- In vitro studies examined CD31's effect on macrophages.
Main Results:
- P8RI treatment shifted macrophages from a proinflammatory to a reparative (M2) phenotype.
- P8RI administration prevented aneurysmal changes by promoting hematoma resolution and collagen production.
- CD31 deficiency enhanced proinflammatory macrophage polarization.
Conclusions:
- CD31 signaling facilitates the transition of macrophages to a reparative state, promoting aortic healing.
- A drug-suitable CD31 agonist like P8RI shows promise for managing ADIM.
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