Related Experiment Video

Updated: Feb 8, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
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Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

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Pharmacological Interventions for Vascular Targeting in Retinopathy of Prematurity: An Experimental Study

Neelima Aron, Madhu Nath, Shorya Vardhan Azad

    Indian Journal of Physiology and Pharmacology
    |June 30, 2018
    PubMed
    Abstract

    Insights

    Bryostatin effectively reduced abnormal blood vessel growth in a Retinopathy of Prematurity (ROP) model, showing promise for treating this eye condition in premature infants.

    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Developmental Biology

    Background:

    • Retinopathy of Prematurity (ROP) is a leading cause of blindness in premature infants.
    • Vascular proliferation in the retina is a hallmark of ROP, leading to vision impairment.

    Purpose of the Study:

    • To evaluate pharmacological interventions for targeting vascular proliferation in Retinopathy of Prematurity (ROP).
    • To assess the efficacy of Bryostatin, Dolastatin 10, Bevacizumab, and Thalidomide in an ROP model.

    Main Methods:

    • Screening of Bryostatin, Dolastatin 10, Bevacizumab, and Thalidomide in a rat model of ROP.
    • Evaluation of retinal vasculature using tortuosity indices.
    • Assessment of electroretinography responses (b wave amplitude) on postnatal days 17 and 25.

    Main Results:

    • ROP presented as vessel tortuosity, primarily affecting arteries.
    • Bryostatin demonstrated the maximum reduction in vessel tortuosity.
    • Bryostatin treatment correlated with the highest 'b' wave amplitude in electroretinography.

    Conclusions:

    • Bryostatin exhibits a potential anti-angiogenic effect in the progression of ROP.
    • Bryostatin may offer a promising therapeutic strategy for treating Retinopathy of Prematurity.

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