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Maintenance of multidomain neurocognitive functions in pediatric patients after proton beam therapy: A prospective

Chi-Cheng Yang1, Shinn-Yn Lin2,3,4, Chen-Kan Tseng2,3

  • 1Department of Psychology, National Chengchi University , Taipei , Taiwan.

Applied Neuropsychology. Child
|June 30, 2018
PubMed

Insights

Proton Beam Therapy (PBT) offers promising neurocognitive outcomes in pediatric brain tumor patients. This study suggests PBT may maintain multidomain neurocognitive functions, unlike traditional X-ray therapy.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Pediatric Neuro-oncology

Background:

  • Radiation therapy for pediatric brain tumors can cause significant neurocognitive deficits.
  • Proton Beam Therapy (PBT) is an advanced radiotherapy technique aiming to reduce radiation-induced side effects.
  • Evaluating long-term neurocognitive outcomes is crucial for pediatric cancer survivors.

Purpose of the Study:

  • To assess the neurocognitive functions (NCF) in pediatric patients treated with Proton Beam Therapy (PBT).
  • To compare NCF outcomes between PBT and conventional photon radiotherapy (XRT).

Main Methods:

  • Retrospective analysis of 8 pediatric patients with brain tumors.
  • Patients received either PBT or XRT.
  • Comprehensive neurocognitive assessments including intelligence, memory, executive functions, and attention.

Main Results:

  • Most patients demonstrated average-to-superior neurocognitive function levels post-treatment.
  • Two patients receiving XRT showed a decline in executive functions.
  • No significant decline in multidomain NCF was observed in patients treated with PBT.

Conclusions:

  • PBT may preserve multidomain neurocognitive functions in pediatric brain tumor patients.
  • This study provides preliminary evidence supporting PBT's potential to minimize radiation-related cognitive impairment.
  • Further research with larger cohorts is warranted to confirm these findings.

Keywords:
MaintenanceProton Beam Therapyneurocognitive functionspediatricprospective

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