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Addressing Administration Challenges Associated With Blinatumomab Infusions: A Multidisciplinary Approach
Stephanie Szoch1, Christina Boord, Alison Duffy
1University of Maryland Medical Center, Baltimore, Maryland. Stephanie Szoch, BSN, RN, OCN®, is a senior clinical nurse II at the University of Maryland Medical Center (UMMC). She chairs the cancer center's Clinical Practice Council and has participated in transitioning vincristine infusions to minibags at UMMC, as well as in other process improvement initiatives to reduce chemotherapy errors. Christina Boord, BSN, RN, OCN®, is a clinical practice and education specialist at UMMC. She sits on several hospital- and system-wide committees working to improve patient-centered care. She is passionate about supporting staff in education and process improvement initiatives to reduce chemotherapy errors. Alison Duffy, PharmD, BCOP, is a clinical specialist in hematology/oncology at UMMC. Dr Duffy is a clinical assistant professor at the University of Maryland School of Pharmacy, as well as the medication safety cochair for the Maryland Society of Health-System Pharmacy. Her interests are in clinical outcomes and practice-based research specifically related to immunocompromised hosts and patients with hematologic malignancies, as well as oncology-related medication safety. Ciera Patzke, PharmD, is a pharmacy resident practicing at UMMC, where she is completing a postgraduate year 2 oncology pharmacy residency through the University of Maryland School of Pharmacy.
Abstract:
Blinatumomab has shown great potential for patients with chemotherapy-resistant B-cell acute lymphocytic leukemia. Blinatumomab's toxicity profile includes central nervous system toxicities, as well as cytokine release syndrome. Although neurological toxicities associated with blinatumomab are almost always reversible, early detection and intervention of these toxicities is vital to ensure that patients continue their full course of treatment. Guidelines for the preparation and administration of blinatumomab in both inpatient and outpatient settings, as well as a standardized neurological nursing assessment, were developed to ensure safe and effective administration of blinatumomab.
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