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Updated: Feb 8, 2026
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Radiation therapy in renal cell carcinoma
Francesca De Felice1, Vincenzo Tombolini1
1Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Viale Regina Elena 326, 00161, Rome, Italy.
Critical Reviews in Oncology/Hematology
|July 1, 2018
Summary
Renal cell carcinoma (RCC) is resistant to traditional radiation therapy (RT). However, high-dose RT shows promise for treating primary and oligometastatic RCC, offering new therapeutic strategies.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Renal cell carcinoma (RCC) traditionally exhibits high resistance to conventional fractionated radiation therapy (RT).
- Emerging evidence suggests radiosensitivity in RCC when treated with high fraction doses of RT.
Purpose of the Study:
- To review the current role of radiation therapy (RT) in managing renal cell carcinoma (RCC).
- To explore the potential therapeutic applications of RT in primary and oligometastatic RCC.
- To focus on significant clinical trials investigating RT for RCC.
Main Methods:
- Literature review of clinical trials and scientific data.
- Analysis of radiosensitivity of renal cell carcinoma (RCC) to different radiation therapy (RT) fractionation schedules.
Main Results:
- Classical fractionated radiation therapy (RT) is generally ineffective for renal cell carcinoma (RCC).
- High-dose fractionated radiation therapy demonstrates radiosensitivity in RCC.
- This radiosensitivity presents opportunities for novel treatment strategies.
Conclusions:
- Radiation therapy (RT) may have a significant role in treating primary and oligometastatic renal cell carcinoma (RCC).
- High-dose RT represents a promising approach for RCC management.
- Further clinical trials are essential to define the optimal RT strategies for RCC.
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