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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

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The multifaceted role of glutathione S-transferases in cancer

Anupam Chatterjee1, Sanjay Gupta2

  • 1Department of Biotechnology & Bioinformatics, North-Eastern Hill University, Shillong, Meghalaya, 793022, India.

Cancer Letters
|July 1, 2018
PubMed

Insights

Glutathione S-transferases (GSTs) are crucial phase II detoxifying enzymes. This review explores their role in cancer, highlighting GSTP1 as a potential biomarker for early detection and targeted therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Glutathione S-transferases (GSTs) are phase II enzymes vital for cellular defense against oxidative stress and DNA damage.
  • While GST synthesis and salvage pathways are known, their regulatory mechanisms in carcinogenesis remain incompletely understood.

Purpose of the Study:

  • To review the multifaceted roles of GSTs in cancer development, progression, and treatment.
  • To explore GST gene polymorphism, drug resistance, signaling pathways, and epigenetic regulation in cancer.
  • To assess the potential of GSTs, particularly GSTP1, as biomarkers for cancer detection and therapeutic targets.

Main Methods:

  • Literature review of studies on GSTs in carcinogenesis.
  • Analysis of research on GST gene polymorphism and its impact on cancer risk.
  • Examination of evidence regarding GSTs in drug resistance and epigenetic modifications in cancer.
  • Evaluation of GSTs as potential biomarkers for cancer diagnosis and therapy.

Main Results:

  • GSTs play significant roles in various stages of cancer development and progression.
  • GST gene polymorphisms are associated with altered cancer susceptibility and outcomes.
  • GSTs contribute to chemoresistance and are implicated in cancer-related signaling and epigenetic alterations.
  • The GSTP1 class shows promise as a biomarker for early cancer detection and personalized treatment strategies.

Conclusions:

  • GSTs are critical players in cancer biology, influencing susceptibility, progression, and treatment response.
  • Targeting GSTs or utilizing them as biomarkers offers potential for improved cancer management.
  • Further research into GSTs, especially GSTP1, could lead to novel diagnostic and therapeutic approaches in oncology.
Keywords:
BiomarkersCarcinogenesisDrug resistanceGlutathione-S transferaseTumor suppressor

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