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Updated: Feb 8, 2026

Guidelines and Experience Using Imaging Biomarker Explorer IBEX for Radiomics
Published on: January 8, 2018
LIFEx: A Freeware for Radiomic Feature Calculation in Multimodality Imaging to Accelerate Advances in the
Christophe Nioche1, Fanny Orlhac1, Sarah Boughdad1
1Imagerie Moléculaire In Vivo, CEA, Inserm, Univ Paris Sud, CNRS, Université Paris Saclay, Orsay, France.
LIFEx is a free, user-friendly software for extracting radiomic features from various medical images. This tool aids in analyzing tumor heterogeneity and supports radiomic models for improved patient management.
Area of Science:
- Medical Imaging
- Radiomics
- Computational Biology
Background:
- Textural and shape analysis are crucial for characterizing tumor heterogeneity in medical imaging.
- Radiomic models require robust feature extraction from diverse imaging modalities.
Purpose of the Study:
- To introduce LIFEx, a free, multiplatform freeware for calculating radiomic features.
- To facilitate multicenter studies on the utility of radiomic features for tumor heterogeneity analysis and patient management.
Main Methods:
- LIFEx calculates conventional, histogram-based, textural, and shape features.
- It supports PET, SPECT, MR, CT, and US images, individually or combined.
- The software requires no programming skills and offers interactive textural analysis options.
Main Results:
- LIFEx is a user-friendly, multiplatform freeware.
- It enables feature extraction from various imaging modalities.
- The software supports a large user community, fostering collaborative development.
Conclusions:
- LIFEx provides a valuable tool for medical imaging professionals.
- It supports the advancement of radiomics for tumor heterogeneity assessment.
- The software promotes reproducible and multicenter research in radiomics.
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