Related Experiment Video
Updated: Feb 8, 2026
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Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
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Pathology, Chemoprevention, and Preclinical Models for Target Validation in Barrett Esophagus
Aleksandra M Urbanska1, Selvarangan Ponnazhagan2, Masoud Mozafari3,4,5
1Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York.
Cancer Research
|July 1, 2018
Summary
Barrett esophagus (BE) increases esophageal adenocarcinoma (EAC) risk. This review examines animal models and chemoprevention strategies to understand BE progression and prevent EAC, crucial for improving patient outcomes.
Area of Science:
- Gastroenterology
- Oncology
- Translational Medicine
Background:
- Esophageal adenocarcinoma (EAC) is a prevalent gastrointestinal cancer.
- Barrett esophagus (BE) significantly elevates EAC risk (11-fold).
- Current EAC prognosis remains poor, necessitating better understanding of BE progression.
Purpose of the Study:
- To review established animal models for studying BE.
- To identify potential chemoprevention targets for Barrett-related EAC.
- To discuss methodological considerations in relevant research.
Main Methods:
- Exploration of genetic animal models of BE.
- Review of surgical and nonsurgical approaches in BE models.
- Analysis of chemoprevention strategies and their rationale.
Main Results:
- Established animal models provide insights into BE biology.
- Various genetic and experimental approaches are available for BE research.
- Chemoprevention targets are being identified to prevent EAC.
Conclusions:
- Animal models are essential for understanding BE progression to EAC.
- Targeted chemoprevention strategies hold promise for EAC prevention.
- Methodological rigor is key for feasible and impactful research in this field.
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