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Updated: Feb 8, 2026

Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
Published on: July 28, 2023
Diagnosis of Helicobacter pylori infection : A short review
Ante Tonkic1,2, Jonatan Vukovic3,4, Pavle Vrebalov Cindro4
1School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia. ante.tonkic@hi.htnet.hr.
Abstract:
Helicobacter pylori infections represent an important factor in the pathogenesis of chronic gastritis, peptic ulcer, MALT lymphoma and gastric adenocarcinoma. The recently published Maastricht V/Florence consensus report indicated that the urea breath test using 13 C urea still remains the best non-invasive test to diagnose H. pylori infections with high sensitivity and specificity. Among the stool antigen tests, the ELISA monoclonal antibody test is a rational option. Effective therapy should be based only on susceptibility testing in regions with documented high clarithromycin resistance (>15%). Advanced high-resolution endoscopic technologies enable increased diagnostic accuracy for detection of H. pylori infections.
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