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Gallbladder bile: an experimental study in dogs using MR imaging and proton MR spectroscopy
Radiology
|November 1, 1985
Summary
Magnetic resonance imaging (MRI) revealed signal intensity differences in dog gallbladder bile. These variations in bile MRI signal intensity are linked to changes in water proton relaxation times.
Area of Science:
- Veterinary Radiology
- Biophysics
- Gastroenterology
Background:
- Gallbladder bile composition varies with physiological state.
- Magnetic resonance (MR) imaging can detect biochemical differences in bile.
Purpose of the Study:
- To investigate MR signal intensity (SI) differences in dog gallbladder bile.
- To correlate SI variations with bile concentration and physiological state.
Main Methods:
- Magnetic resonance (MR) imaging and proton MR spectroscopy were used.
- Biochemical analysis of gallbladder bile was performed.
- Studies included fasting and sincalide-treated dogs.
Main Results:
- High MR SI was observed in fasting dog bile; low to medium SI in sincalide-treated dog bile.
- Proton MR spectra were similar between groups.
- Fasting dog bile had lower water content and higher concentrations of cholesterol, phospholipids, and bile acids.
Conclusions:
- Differences in gallbladder bile MR SI are attributed to altered water proton relaxation times.
- Macromolecular interactions likely influence water proton relaxation in bile.