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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
07:39

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

Published on: April 13, 2021

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Applications of kidney organoids derived from human pluripotent stem cells

Yong Kyun Kim1,2, Sun Ah Nam1,2, Chul Woo Yang2,3

  • 1Cell Death Disease Research Center, The Catholic University of Korea, Seoul, Korea.

The Korean Journal of Internal Medicine
|July 3, 2018
PubMed

Insights

Human pluripotent stem cells are used to create kidney organoids for regenerative medicine. Advances in genome editing and bioprinting enhance their use in disease modeling, drug screening, and regenerative therapy.

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Human pluripotent stem cells can be differentiated into kidney organoids.
  • Kidney organoids offer potential for regenerative medicine applications.
  • Significant progress has been made in kidney organoid development.

Purpose of the Study:

  • To review recent advances in kidney organoid applications.
  • To highlight the use of kidney organoids in clinical fields.
  • To discuss kidney organoids in disease modeling, drug screening, and regenerative therapy.

Main Methods:

  • Review of recent scientific literature.
  • Focus on advancements in clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated system 9 (Cas9) genome editing.
  • Integration of three-dimensional bioprinting technologies.

Main Results:

  • Kidney organoids show promise in modeling renal diseases.
  • Applications include drug screening and nephrotoxicity testing.
  • Regenerative therapy is a key potential application.

Conclusions:

  • Kidney organoids are valuable tools for kidney research and therapy.
  • CRISPR-Cas9 and 3D bioprinting accelerate clinical applications.
  • Further development holds significant therapeutic potential.
Keywords:
Clustered regularly interspaced short palindromic repeatsKidneyOrganoidsTransplantationBioprinting

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