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Updated: Feb 8, 2026
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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
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A Newborn With Hyperlactatemia and Epileptic Encephalopathy
Rawad Obeid1, Yoshimi Sogawa2, Monica Naik2
1Department of Neurology, Children's National Health System, Washington, DC.
Seminars in Pediatric Neurology
|July 3, 2018
Summary
Diagnosing hyperlactatemia in newborns is complex. This article presents a diagnostic approach using clinical history, labs, and brain imaging to guide the workup.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Clinical Diagnostics
Background:
- Hyperlactatemia in newborns presents a diagnostic challenge.
- Accurate etiological diagnosis is crucial for appropriate management.
- Current diagnostic strategies may lack a structured approach.
Observation:
- This article proposes a diagnostic paradigm for neonatal hyperlactatemia.
- The paradigm integrates clinical history, laboratory findings, and brain imaging.
- This systematic approach aims to streamline the diagnostic process.
Findings:
- The proposed diagnostic paradigm aids in identifying the cause of hyperlactatemia.
- Utilizing clinical, laboratory, and imaging data improves diagnostic accuracy.
- This framework helps differentiate various etiologies of elevated lactate.
Implications:
- Implementing this paradigm can lead to timely and targeted interventions.
- Improved diagnostic accuracy may reduce morbidity and mortality associated with hyperlactatemia.
- This approach can serve as a valuable tool for clinicians managing neonates with hyperlactatemia.
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