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Sarcoidosis in Patients with Antisynthetase Syndrome: Presentation and Outcome
Priscille Couture1,2, Pierre-Yves Brillet3,4, Stéphane Varin3,4
1From the AP-HP, Hôpital Avicenne, Service de Pneumologie; AP-HP, Hôpital Avicenne, Service de Radiologie, Bobigny; Centre hospitalier départemental de Vendée, Hôpital La Roche-sur-Yon, Service de Rhumatologie, Les Oudairies, La Roche-sur-Yon; Centre Hospitalier Universitaire de Nantes, Service de Rhumatologie, Nantes; Centre de Référence des Maladies Auto-immunes Rares, Service de Rhumatologie, Strasbourg; Centre Hospitalier Universitaire de Rennes, Service de Pneumologie, Rennes; AP-HP, Hôpital Pitié-Salpêtrière, Département de Médecine Interne et Immunologie Clinique, Centre National de Référence des Maladies Musculaires, Paris, France. couture.priscille@gmail.com.
Objective:
To investigate the uncommon co-occurrence of antisynthetase syndrome (AS) and sarcoidosis.
Methods:
From 2000 to 2015, patients with sarcoidosis were extracted from a retrospective multicentric cohort of 352 patients with AS.
Results:
Ten patients (2.8%; 6 men, 8 whites, 5 smokers, median age 50 yrs) had both AS and sarcoidosis. Most of the time, sarcoidosis and AS occurred simultaneously (n = 7). Antibody testing revealed anti-Jo1 (n = 5), anti-PL12 (n = 4), or anti-PL7 (n = 1). Finally, no patient had a worsening of muscular condition, 5 patients presented respiratory deterioration, 3 remained stable, and 2 showed improvement.
Conclusion:
Sarcoidosis may be underdiagnosed in patients with AS.
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