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LncCeRBase: a database of experimentally validated human competing endogenous long non-coding RNAs.

Cong Pian1, Guangle Zhang2, Tengfei Tu3

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This study introduces LncCeRBase, a new database of experimentally verified human competing endogenous RNAs (ceRNAs). LncCeRBase details long non-coding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) interactions crucial for cancer regulation.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
  • Competing endogenous RNAs (ceRNAs), including lncRNAs, modulate microRNA (miRNA) activity.
  • ceRNAs are implicated in the development and progression of various cancers.

Purpose of the Study:

  • To establish the first comprehensive database of experimentally validated human ceRNAs.
  • To provide a resource for investigating lncRNA-mediated gene regulation in diseases.
  • To facilitate research into the functional roles of lncRNA-miRNA-mRNA interactions.

Main Methods:

  • Curated data from 300 publications on lncRNA-miRNA-mRNA interactions.
  • Development of the LncCeRBase database.
  • Inclusion of associated signaling pathways for functional analysis.

Main Results:

  • The LncCeRBase database contains 432 interactions involving 130 lncRNAs, 214 miRNAs, and 245 genes.
  • The database represents a significant collection of experimentally verified human ceRNAs.
  • Associated signaling pathways offer insights into the functional context of these interactions.

Conclusions:

  • LncCeRBase serves as a valuable resource for understanding lncRNA regulatory mechanisms.
  • The database supports research into the role of ceRNAs in human diseases, particularly cancer.
  • This resource aids in exploring the complex network of lncRNA-miRNA-mRNA interactions.